At Kramer's insistence, George parks his Dad's car in a handicap spot. After a woman is injured because of it, George becomes his Dad's butler while Kramer tries to help the woman.
Sheldon goes to Vegas to win money for science. Also, Penny and Bernadette take Amy wedding dress shopping, but her terrible choice entangles them in a web of lies.
Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements. Mary discovers that Georgie is working at Meemaw's illegal gambling room.
When Dr. Sturgis recommends Sheldon and Missy for a university research study on twins, Mary is unhappy when the test results go to Sheldon's head.
Kat wins a free trip to Puerto Rico for herself and a friend, but she doesn't have anyone to go with her. After being left in charge of the cafe, Randi and Phil have trouble with the new register.
Gina brings her dog Cannoli to the retirement home where he bonds with the seniors. Drew prepares for his new life driving cross country in a camper van.
Barry Kripke pranks Sheldon during his spot on NPR, leaving him with a taste for vengeance. Wolowitz, pressured by Bernadette to define their relationship, gets advice from a fantasy version of Katee Sackhoff.
Penny seeks Sheldon's help to better comprehend Leonard's physics work. Wolowitz sees green when Leonard invites Bernadette to watch an experiment.